The parietal cortex has a causal role in ambiguity computations in humans

Valdebenito-Oyarzo, Gabriela; Martinez-Molina, Maria Paz; Soto-Icaza, Patricia; Zamorano, Francisco; Figueroa-Vargas, Alejandra; Larrain-Valenzuela, Josefina; Stecher, Ximena; Salinas, Cesar; Bastin, Julien; Valero-Cabre, Antoni; Polania, Rafael; Billeke, Pablo; Rushworth, Matthew F. S.; Smith, Lucas

Abstract

--- - Humans often face the challenge of making decisions between ambiguous options. The level of ambiguity in decision-making has been linked to activity in the parietal cortex, but its exact computational role remains elusive. To test the hypothesis that the parietal cortex plays a causal role in computing ambiguous probabilities, we conducted consecutive fMRI and TMS-EEG studies. We found that participants assigned unknown probabilities to objective probabilities, elevating the uncertainty of their decisions. Parietal cortex activity correlated with the objective degree of ambiguity and with a process that underestimates the uncertainty during decision-making. Conversely, the midcingulate cortex (MCC) encodes prediction errors and increases its connectivity with the parietal cortex during outcome processing. Disruption of the parietal activity increased the uncertainty evaluation of the options, decreasing cingulate cortex oscillations during outcome evaluation and lateral frontal oscillations related to value ambiguous probability. These results provide evidence for a causal role of the parietal cortex in computing uncertainty during ambiguous decisions made by humans. - Humans often face the challenge of making decisions between ambiguous options. The level of ambiguity in decision-making has been linked to activity in the parietal cortex, but what is its actual role? This study uses fMRI and TMS-EEG to show that the parietal cortex is causally involved in a computational processes that underestimate uncertainty during decision-making under ambiguity.

Más información

Título según WOS: ID WOS:001142526300001 Not found in local WOS DB
Título de la Revista: PLoS Biology
Volumen: 22
Número: 1
Editorial: PUBLIC LIBRARY SCIENCE
Fecha de publicación: 2024
DOI:

10.1371/journal.pbio.3002452

Notas: ISI