Article ISI SCOPUS
ARCHIV DER PHARMAZIE  (2009)

Synthesis and Cytotoxic Evaluation of 6-(3-Pyrazolylpropyl) Derivatives of 1,4-Naphthohydroquinone-1,4-diacetate

Molinari, A; Oliva A.; Ojeda, C.; del Corral, JMM; Cuevas, C; Feliciano, AS

Abstract

Several new 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1, 4-diacetate (NHQ-DA) have been prepared by chemical modifications of the Diels-Alder adduct of a-myrcene and 1,4-benzoquinone. All these new compounds and precursors have been evaluated in vitro for their cytotoxicity against cultured human cancer cells of MB-231 breast-adeno carcinoma, A-549 lung carcinoma, and HT-29 colon carcinoma. GI50 values ranged in and below the micromolar concentration level. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

Más información

Título según WOS: Synthesis and Cytotoxic Evaluation of 6-(3-Pyrazolylpropyl) Derivatives of 1,4-Naphthohydroquinone-1,4-diacetate
Título según SCOPUS: Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate
Título de la Revista: ARCHIV DER PHARMAZIE
Volumen: 342
Número: 10
Editorial: WILEY-V C H VERLAG GMBH
Fecha de publicación: 2009
Página de inicio: 591
Página final: 599
Idioma: English
URL: http://doi.wiley.com/10.1002/ardp.200900041
DOI:

10.1002/ardp.200900041
Notas: ISI, SCOPUS