Abstract

Purpose: Pembrolizumab demonstrated efficacy in PD-L1-positive [combined positive score (CPS) >= 1] advanced gastric/gastro-esophageal junction (G/GEJ) cancer in the first-, second-, and third-line setting in KEYNOTE-062, KEYNOTE-061, and KEYNOTE-059, respectively. To better delineate the specificity of CPS as a predictor of dinical outcomes, we analyzed pembrolizumab efficacy in patients with CPS >= 10 in these trials.