Mechanisms of directional asymmetry in the zebrafish epithalamus

Concha, ML; Signore, IA; Colombo, A

Abstract

The epithalamus of zebrafish presents the best-studied case of directional asymmetry in the vertebrate brain. Epithalamic asymmetries are coupled to visceral asymmetry and include left-sided migration of a single midline structure (the parapineal organ) and asymmetric differentiation of paired bilateral nuclei (habenulae). The mechanisms underlying the establishment of epithalamic asymmetry involve the interplay between anti-symmetry and laterality signals to guide asymmetric parapineal migration. This event triggers the amplification of habenular asymmetries and the subsequent organisation of lateralised circuits in the interpeduncular nucleus. This review will summarise our current understanding on these processes and propose a sequential modular organisation of the events controlling the development of asymmetry along the parapineal-habenular-interpeduncular axis. © 2008 Elsevier Ltd. All rights reserved.

Más información

Título según WOS: Mechanisms of directional asymmetry in the zebrafish epithalamus
Título según SCOPUS: Mechanisms of directional asymmetry in the zebrafish epithalamus
Título de la Revista: Seminars in Cell and Developmental Biology
Volumen: 20
Número: 4
Editorial: Elsevier Ltd.
Fecha de publicación: 2009
Página de inicio: 498
Página final: 509
Idioma: eng
URL: http://linkinghub.elsevier.com/retrieve/pii/S1084952108001316
DOI:

10.1016/j.semcdb.2008.11.007

Notas: ISI, SCOPUS