Abstract

The global impact of residues resulting from fishing processing has generated the need to develop sustainable processes, find additional potential of raw materials, and provide alternatives for their recovery of potentially valuable by-products. On the other hand, colorectal cancer (CRC) is the second leading cause of cancer death worldwide and needs novel and more effective treatments. In this study, we extracted and characterized oil from Jumbo squid hepatopancreas and evaluated its antioxidant potential and antiproliferative activity. The oil recovered from the Jumbo squid production process has characteristics that meet international standards. PUFA-rich oil from Jumbo squid hepatopancreas showed high concentrations of EPA/DHA (about 42% of the total fatty acids) and antioxidant potential. The antiproliferative activity evaluated on colorectal cancer cells, HCT116, showed activity against the tumor cells, representing the first evidence for a potential anticancer application. This research proposes a sustainable strategy for achieving a circular bioeconomy by recovering oil from jumbo squid viscera, offering alternatives for valorizing this bioproduct.