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Development of a highly dispersible sustained-release microcapsule as a platform for pulmonary drug delivery through dry powder inhalers
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| Fecha de publicación: | 2019 |
| Objetivos: | To develop a highly dispersible gelatin-based microcapsule, we used gelatin—an FDA-approved excipient—as the matrix to establish ionotropic interactions with ionic APIs and thus control their pulmonary release. Release kinetics were modulated in two ways: (i) electrostatic binding between the API an |
| Instrumento: | Fondecyt de Iniciación en Investigación |
| Año de Inicio/Término: | 2019-2024 |
| Financiamiento/Sponsor: | CONICYT |
| Rol del Usuario: | INVESTIGADOR(A) RESPONSABLE |
| DOI: |
11190987 |
| Notas: | The study showed that adjusting micro-capsule wall thickness effectively modulates the release of COPD- and asthma-targeted APIs.The gelatin microspheres also prolonged lung retention: upon contact with alveolar fluid they swell, increasing their diameter and enabling them to evade macrophage uptake |