Non-invasive method for the early diagnosis of gastric cancer using as a biomarker the methylation levels in the DNA sequence of microRNA-335-5p promoter

Sandoval Borquez, Alejandra; Corvalán, Alejandro

Keywords: dna methylation, gastric cancer, biomarkers, early diagnosis, non-invasive method, microRNA-335-5p, plasma samples

Abstract

The invention is directed to a method for the early detection of gastric cancer, by detecting the increase in DNA methylation of the promoter region of the microRNA-335-5p in samples obtained non-invasively, preferably in plasma. Thus, it is a contribution for the early detection of gastric cancer, without invasive procedures, with rapid collection of the sample and of the delivery of the results, and of lower cost than the technologies that employ invasive diagnostic techniques to the human and animal body in general.

Más información

Fecha de publicación: 2022
URL: https://patentscope.wipo.int/search/es/detail.jsf?docId=US297156646&_cid=P10-M9VTOD-04916-1
DOI:

US11512354B2