Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

Stein, GS; Zaidi, SK; Stein, JL; Lian, JB; van Wijnen, AJ; Montecino, M.; Young, DW; Javed, A; Pratap, J; Choi, JY; Ali, SA; Pande S.; Hassan, MQ

Abstract

Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.

Más información

Título según WOS: Transcription-factor-mediated epigenetic control of cell fate and lineage commitment
Título según SCOPUS: Transcription-factor-mediated epigenetic control of cell fate and lineage commitment
Título de la Revista: Biochemistry and Cell Biology
Volumen: 87
Número: 1
Editorial: National Research Council of Canada
Fecha de publicación: 2009
Página de inicio: 1
Página final: 6
Idioma: eng
URL: http://www.nrcresearchpress.com/doi/abs/10.1139/O08-094
DOI:

10.1139/O08-094

Notas: ISI, SCOPUS