An Fgf8-Dependent Bistable Cell Migratory Event Establishes CNS Asymmetry

Regan, JC; Concha, ML; Roussigne, M; Russell, C; Wilson, SW

Abstract

Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated by the failure of the parapineal nucleus to migrate from its initial midline position to the left side of the brain. Local provision of Fgf8 restores the asymmetric migration of parapineal cells, usually to the left, irrespective of the location of the Fgf8 source. This laterality bias is due to left-sided Nodal signaling and when the bias in Nodal signaling is removed, parapineal cells migrate toward the source of Fgf8 protein. This study presents a mechanism for breaking neuroanatomical symmetry through Fgf8-dependent regulation of bistable left- or right-sided migration of the parapineal. The combined action of Fgf and Nodal signals ensures the establishment of neuroanatomical asymmetries with consistent laterality. © 2009 Elsevier Inc. All rights reserved.

Más información

Título según WOS: An Fgf8-Dependent Bistable Cell Migratory Event Establishes CNS Asymmetry
Título según SCOPUS: An Fgf8-Dependent Bistable Cell Migratory Event Establishes CNS Asymmetry
Título de la Revista: NEURON
Volumen: 61
Número: 1
Editorial: Cell Press
Fecha de publicación: 2009
Página de inicio: 27
Página final: 34
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0896627308010520
DOI:

10.1016/j.neuron.2008.11.030

Notas: ISI, SCOPUS