Genetics of Hypertensive Syndrome

Martinez-Aguayo, A; Fardella, C.

Abstract

The knowledge of the genetic bases of hypertension has improved over the last decade; this area of research has high priority due to the high incidence of hypertension and its impact on public health. Monogenetic mineralocorticoid hypertension syndromes are associated with suppressed plasma renin activity due to excessive activation of the mineralocorticoid pathway. We review the pathophysiology, phenotype, and method of diagnosis for familial hyperaldosteronism type I and type II, hypertensive forms of congenital adrenal hyperplasia, 11ß-hydroxysteroid dehydrogenase type 2 deficiency, Liddle's syndrome, an activating mutation of the MR, and glucocorticoid resistance. We also review some genes that could contribute to essential hypertension. © 2009 S. Karger AG, Basel.

Más información

Título según WOS: Genetics of Hypertensive Syndrome
Título según SCOPUS: Genetics of hypertensive syndrome
Título de la Revista: Hormone Research
Volumen: 71
Número: 5
Editorial: S. Karger AG
Fecha de publicación: 2009
Página de inicio: 253
Página final: 259
Idioma: eng
URL: http://www.karger.com/doi/10.1159/000208798
DOI:

10.1159/000208798

Notas: ISI, SCOPUS