Article ISI
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION  (2025)

Genetic ancestry and risk allele C9orf72 rs3849942 T for amyotrophic lateral sclerosis in Latin American populations

Flores S.V.; Lillo P.; Levi-Monsalve, A.; Roco-Videla, A.; Montana, R.

Keywords: genetic ancestry, Amyotrophic lateral sclerosis (ALS), Latin American populations, Risk allele

Abstract

This study examines the relationship between genetic ancestry and the rs3849942 T allele, linked to ALS, in 347 Latin American individuals from the 1000 Genomes Project. Ancestry proportions were estimated using 446 AIMs, and associations were analyzed via logistic regression. Higher Native American ancestry significantly reduced the likelihood of carrying the T allele, while European ancestry increased it. These findings emphasize the importance of incorporating genetic diversity into ALS research.

Más información

Título según WOS: Genetic ancestry and risk allele C9orf72 rs3849942 T for amyotrophic lateral sclerosis in Latin American populations
Título de la Revista: AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
Volumen: 26
Número: 3-4
Editorial: TAYLOR & FRANCIS LTD
Fecha de publicación: 2025
Página de inicio: 379
Página final: 381
Idioma: English
DOI:

10.1080/21678421.2024.2447459
Notas: ISI