Abstract

In this work, a nanocomposite (NC) composed of Au nanoprisms and reduced graphene oxide (Au NPRs-RGO NC) was synthesized using orange peel extract (OPE) in the presence of sunlight and employed for electrochemical determination of bovine serum albumin (BSA). The transverse and longitudinal plasmon modes along with RGO absorption characteristics of the Au NPRs-RGO NC were analyzed by UV-Visible absorption spectroscopy. Transmission electron microscopy analysis confirmed the presence of highly crystalline and prism-like morphology with variable sizes of Au NPRs decorated on the RGO surface. The cyclic voltammetry (CV) analysis using Au NPRs-RGO NC modified glassy carbon electrode (GCE) revealed an enhanced catalytic current response for the oxidation of BSA, demonstrating synergistic performance of the Au NPRs and RGO. The Au NPRs-RGO NC modified GCE exhibited a remarkable sensing capability towards BSA in differential pulse voltammetric (DPV) measurements and consequently achieved a detection limit of 0.0084 mu M with a sensitivity of 371.71 mu A mu M- 1 cm- 2. These findings suggest that the Au NPRs-RGO NC is anticipated to hold great potential as a versatile and efficient biosensing platform for the detection of a wide range of human proteins and redox enzymes.