Abstract

Introduction and aim: Due to its elevated prevalence, complex pathophysiology, and broad spectrum of clinical manifestations, gastroesophageal reflux disease (GERD) requires precision diagnosis and treatment. The aim of this Latin American expert review was to provide good clinical practice recommendations for the rational use of diagnostic tests and the personalized treatment of GERD. Methods: Good clinical practice recommendations were developed by a group of Latin American experts in GERD. A thorough review of the literature was conducted, and recommendations on the diagnosis and treatment of GERD were issued after three group discussions. Results: Twenty-one experts on GERD formulated 30 clinical recommendations for appropriately indicating diagnostic tests for disease phenotypes and their medical treatment, refractory GERD management, endoscopic and surgical treatment indications, the control of GERD in obesity, pregnancy, and older adults, as well as the role of Helicobacter pylori infection and GLP-1 agonists. Conclusions: Determining GERD phenotypes in patients through the appropriate use of diagnostic tests enables personalized treatment to be prescribed. The recommendations established in this document may contribute to improving the quality of care of patients with GERD. © 2025 Asociación Mexicana de Gastroenterología