Biocompatibility Assessment of Polycaprolactone/Polylactic Acid/Zinc Oxide Nanoparticle Composites Under In Vivo Conditions for Biomedical Applications (vol 15, 2196, 2025)

Castro J.I.; Araujo-Rodríguez, DG; Valencia-Llano C.H.; Tenorio D.L.; Saavedra M.; Zapata P.A.; Grande-Tovar C.D.

Abstract

In the original publication [1], there was a mistake in Figure 6 as published. We mistakenly duplicated a macroscopic photo of a biomodel implanted with different scaffolds, previously published in [2]. This error occurred because we usually use the same animal biomodels to evaluate different materials simultaneously, employing a subdermal implantation model that allows the creation of up to 10 pockets per animal, each containing a different material. In some cases, two or three different systems were implanted in the same biomodel, as per the experimental design. This experimental strategy optimizes animal use, minimizes inter-individual variability, and facilitates direct comparisons between the materials studied under controlled conditions, thereby complying with the principles of the 3Rs (Replacement, Reduction, and Refinement). The figure in question corresponds to a macroscopic image of the dorsal area of implantation in the biomodel. This type of image is typically included as a preliminary visual representation of the tissue response. It serves as complementary evidence to the histological findings, which constitute the primary support for the article’s conclusions. The figure, intended solely as a preliminary visual context, does not affect the scientific validity, results, or conclusions of the article. The corrected Figure 6 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated. © 2025 by the authors.

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Título según WOS: Biocompatibility Assessment of Polycaprolactone/Polylactic Acid/Zinc Oxide Nanoparticle Composites Under In Vivo Conditions for Biomedical Applications (vol 15, 2196, 2025)
Título de la Revista: Pharmaceutics
Volumen: 17
Número: 9
Editorial: Multidisciplinary Digital Publishing Institute (MDPI)
Fecha de publicación: 2025
Idioma: English
DOI:

10.3390/pharmaceutics17091113

Notas: ISI