Abstract

Circadian clocks maintain the correct period despite nutritional fluctuations, a property known as metabolic compensation (MC). In a recent report, Sárkány et al. reveal a conserved role for Ras guanine nucleotide exchange factor (RasGEF) signaling in MC from fungi to human cells. Their findings highlight how this pathway buffers circadian function under glucose deprivation, integrating metabolic cues into clock dynamic robustness. © 2025 Elsevier Ltd