Abstract

Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. Our main objective is to assess the test accuracy of any multidomain cognitive test delivered remotely for the diagnosis of any form of dementia. Our review will not be limited to a particular healthcare setting or a particular threshold score of index test. Secondary objectives To describe the degree of agreement between a remotely delivered cognitive test and the same or a closely related test delivered in-person when neither is assessed against a clinical dementia reference standard. To identify the quality and quantity of the research evidence describing test accuracy of remote testing. To identify sources of heterogeneity in the test accuracy described. To identify gaps in the evidence where further research is required. Investigation of sources of heterogeneity Heterogeneity is often seen in clinical test accuracy reviews (Deeks 2001). Important potential sources of heterogeneity will include the case-mix of the population being assessed; clinical setting; person performing the assessment; platform used to administer the test (e.g. standard telephone versus video call); threshold scores used to define test positivity; and the quality of the included papers. We will collect data on all of these factors, and if data allow will explore their effect using subgroup and sensitivity analyses as appropriate.