Episodic Memory in Amnestic Mild Cognitive Impairment at Risk for Alzheimer's Disease: Spanish Validation of the TYM-MCI.

Belmar-Moreno, Á., Egaña-García, F., Castillo-Borredá, A., Caballero-Muñoz, E., Gatica-Elgart, V., Crespo, F. A., Salinas-Lainez, P., Muñoz-Ojeda, N., Freire-Flores, D., Carvallo-Varas, C., & Burgos, H.

Keywords: aged, mild cognitive impairment, memory, episodic, cognitive dysfunction, neuropsychological tests, early diagnosis, Mini-Mental State Examination, validation study, dementia

Abstract

Background: Building on the validation of the Your Memory test for mild cognitive impairment in English speakers, this study adapted and validated the Memory Test for Mild Cognitive Impairment (TYM-MCI) for older Spanish-speaking adults, highlighting its potential utility for the early detection of amnestic mild cognitive impairment and cognitive profiles associated with increased risk of dementia. Methods: A total of 151 independently functioning adults aged 60 or older (Barthel Index 9–10) completed the TYM-MCI, the Addenbrooke’s Cognitive Examination-Revised (ACE-R-Ch), the Mini-Mental State Examination, and the original TYM. Analyses included ROC curves, correlation matrices, and principal component analysis (PCA). Results: The TYM-MCI exhibited strong psychometric properties (Cronbach’s α = 0.832; sensitivity = 81.7%; specificity = 47.8%). The optimal cut-off score was ≥24.5/30. Scores between 19 and 24.5 suggested probable mild cognitive impairment (MCI). Conclusions: The episodic memory components of this test are key cognitive features relevant to the modification and monitoring of early cognitive decline and are straightforward to administer. Notably, the TYM-MCI specifically assesses both visual and verbal episodic memory. It can be used alongside other assessments, such as the ACE-R or MMSE, to support the clinical evaluation of cognitive functioning in older adults. Clinically, it provides an early assessment and follow-up in individuals presenting with memory complaints, contributing to timely clinical decision-making in the context of cognitive decline.

Más información

Título de la Revista: Journal of clinical medicine
Volumen: 15
Número: 3
Fecha de publicación: 2026
Página de inicio: 1
Página final: 32
Idioma: English
Financiamiento/Sponsor: Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
DOI:

PMCID: PMC12898810 PMID: 41682915

Notas: SCOPUS