Abstract

ObjectiveThis systematic review and meta-analysis compared the clinical performance of direct restorations using conventional or bulk-fill resin composites (RC) with self-adhesive RCs in permanent teeth, regardless of cavity type or adhesive strategy employed. PICOS question was "Do direct restorations using self-adhesive RC exhibit clinical performance comparable to that of conventional or bulk-fill RCs?"MethodsSearch strategy was applied across Medline/PubMed, Web of Science, Scopus, Embase, LILACS, The Cochrane Library, Base, Google Scholar, and OpenGray databases on January 17th, 2024 and updated on May 5th, 2025. Randomized clinical trials that evaluated the clinical performance of direct restorations with self-adhesive RC compared to conventional or bulk-fill RC in permanent teeth were included. Risk of bias was assessed using the RoB 2 tool. All analyses were performed using RevMan 5 with Risk Difference (RD) and corresponding 95% confidence intervals (CIs). Random-effects models and the Mantel-Haenszel method were applied.Results1206 articles were identified. 12 studies (15 reports) were included in qualitative and quantitative analyzes. A total of 356 participants aged 6 to 79 years received 794 restorations, of which 396 were performed with conventional or bulk-fill RCs and 398 with self-adhesive RCs. The follow-up period ranged from immediately after restoration (baseline) to 60 months. Meta-analyses revealed that no significant differences were found between the RCs across all the evaluated outcomes: marginal staining (P >= 0.13), color stability (P >= 0.27), fracture/retention (P >= 0.45), and marginal adaptation (P >= 0.08) regardless of the follow-up periods. For wear, postoperative sensitivity, and recurrence of caries, erosion, or abrasion, effects estimates were not possible. From 12 included studies, 6 of them showed a high overall risk of bias. Certainty of evidence was considered low or very low across all the evaluated criteria mainly due to imprecision and risk of bias.ConclusionThe low certainty of evidence suggests that self-adhesive RC direct restorations demonstrate clinical performance similar to conventional or bulk-fill RCs across all cavity types over a follow-up period of 6 to 48 months.