Omeprazole, a specific gastric secretion inhibitor on oxynticopeptic cells, reduces gizzard erosion in broiler chicks fed with toxic fish meals

Hinrichsen J.P.; Neira M.; López C.; Chiong M.; Ocaranza M.P.; Gallardo R.; Rutman, M; Blamey, J.; Lavandero S.

Keywords: acid, size, enzyme, animals, weight, mortality, diet, food, fishes, products, secretion, fish, experiment, diseases, male, agents, acidity, omeprazole, atpase, inhibitor, dose, chicken, gain, drug, stomach, vomiting, inhibitors, article, dose-response, oral, chickens, poisoning, feed, poultry, organ, controlled, animal, determination, gastric, study, response, priority, administration, nonhuman, journal, Relationship,, Avian, Administration,, Anti-Ulcer, Gizzard, H(+)-K(+)-Exchanging

Abstract

The relation between gizzard erosion-black vomit (GE-BV) and gastric secretion is not completely understood A pharmacological approach to reduce the presence of GE BV in chicks due to fish meal in diets is also unknown. In this study the use of omeprazole, a H +/K + ATPase inhibitor, and fish meals of different biotoxicological characteristics, showed that: 1) Omeprazole decreased total gastric acid content, GE scores and severe GE (SGE) cases, in a dose dependent manner. This reduction was significant at levels higher than 20 mg omeprazole/Kg body weight (BW)/day (p < 0.01). The addition of 50 mg omeprazole/kg BW/day almost completely prevented the incidence of SGE cases and reduced in 50% GE score in chicks (p < 0.01). 2) A significant reduction in specific mortality, near 90%, was also seen with all toxic fish meals when omeprazole (50 mg/Kg DW/day) was added to experimental diets in comparison to control groups. However, no mortality was observed when omeprazole was added to diets containing non-toxic fish meals. 3) In chicks fed with toxic fish meals, addition of different amounts of omeprazole to diets changed the relative weight of proventriculus (p < 0.01) and gizzard (P < 0.05). Maximum effect was obtained with omeprazole concentration higher than 50 mg/kg BW/day. 4) Omeprazole did not change feed intake in chicks fed with toxic fish meal. However, in some fish meal a reduction on weight gain was observed with the addition of omeprazole.

Más información

Título de la Revista: Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
Volumen: 117
Número: 3
Editorial: Society of Laparoendoscopic Surgeons
Fecha de publicación: 1997
Página de inicio: 267
Página final: 273
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0030808903&partnerID=q2rCbXpz
DOI:

10.1016/S0742-8413(97)00067-4