Abstract

Treatment of the ketones 1, 5, 7 with Grignard reagents yielded the products 4, 6, 8, respectively. The ester 9 with Grignardreagent followed by alkaline hydrolysis afforded lactones 10 and 11, respectively. The lactones 14 and 17 on being treatedwith Grignard reagent furnished the diketone 15 and the chloroketone 18 respectively. The epoxide 19 with Grignard reagentproduced diol 21 whereas the epoxide 22 suffered ring contraction yielding the aldehyde 23.