Article
PHARMAZIE  (1998)

1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins: Structure-activity relationships

Monge, A; Lopez De Cerain A.; Ezpeleta, O; Cerecetto, H.; Dias E.; Di Maio, R; Gonzalez, M.; Onetto, S; Risso, M; Seoane, G; Zinola F.; Olea Azar C.

Keywords: synthesis, structure, hypoxia, mechanism, oxide, radical, drug, cytotoxin, article, activity, lipophilicity, controlled, relation, study, oxadiazole, calculation, derivative, Free, unclassified, n, 1,2,5, furazan, tirapazamine

Abstract

Structure-activity relationship studies on a series of 1,2,5-oxadiazole N-oxide derivatives showing cytotoxic activity have been performed. The mechanism of action could be related with free radical production.

Más información

Título de la Revista: PHARMAZIE
Volumen: 53
Número: 10
Editorial: GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
Fecha de publicación: 1998
Página de inicio: 698
Página final: 702
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031693970&partnerID=q2rCbXpz