Abstract

Liver fibrosis is a complex process characterized by excessive accumulation of extracellular matrix (ECM) associated with chronic injury inflammation and an alteration of liver architecture as a result of most types of chronic liver diseases such as cirrhosis, hepatocellular carcinoma and liver failure. The ω-3 Docosahexaenoic (DHA) fatty acids and their derivative Maresin-1 (MaR1) have been shown to have pro-resolutive, anti-inflammatory, and hepatoprotective liver effects on acute models of liver study, but their role in apoptosis and liver regeneration remains to be elucidated. This study aimed to analyze the role of DHA+MaR1 in the prevention and restoration of liver fibrosis damage, enhancing a regenerative phenotype in an animal model of chronic liver damage.