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Molecular interactions of acetylcholinesterase with senile plaques
Keywords: substrate, inhibition, enzyme, amyloid, animals, complex, protein, cell, gene, inactivation, disease, alpha, beta, mutation, humans, human, paper, interaction, acetylcholinesterase, assembly, formation, drug, molecular, alzheimer, plaque, activity, neuropathology, helix, plaques, effect, conference, senile
Abstract
Acetylcholinesterase (ACHE) present in Alzheimer plaques is resistant to low pH, anti-ChE inhibitors and high substrate concentrations in comparison with the free enzyme. Kinetic and pharmacological studies of AChE-amyloid complexes indicate that steric hindrance by the amyloid over the gorge and the peripheral site of AChE is responsible for these effects.
Más información
| Título de la Revista: | JOURNAL OF PHYSIOLOGY-PARIS |
| Volumen: | 92 |
| Número: | 5-6 |
| Editorial: | EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| Fecha de publicación: | 1998 |
| Página de inicio: | 341 |
| Página final: | 344 |
| URL: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0032440687&partnerID=q2rCbXpz |
| DOI: |
10.1016/S0928-4257(99)80002-3 |
| Notas: | ISI |