Article
Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology  (1999)

Effects of some ?-carboline alkaloids on intact Trypanosoma cruzi epimastigotes

Rivas, P; Cassels, B.K.; Morello A.; Repetto Y

Keywords: kinetics, sensitivity, oxygen, animals, trypanosoma, chain, beta, specificity, consumption, strain, agents, species, nifurtimox, agent, drug, article, difference, respiratory, activity, cruzi, controlled, alkaloid, antiprotozoal, carboline, study, derivative, priority, nonhuman, journal, antitrypanosomal, Trypanocidal, epimastigote, harmaline, harman, harmine, Carbolines

Abstract

Several ?-carboline (9H-pyrido-[3,4-b]-indole) alkaloids were evaluated for in vitro trypanosomicidal activity against Trypanosoma cruzi epimastigotes belonging to two different strains (Tulahuen and LQ) showing different sensitivity to nifurtimox. Important differences were observed in the susceptibility of the parasites to these natural substances, with the relatively nifurtimox-resistant LQ strain showing greater sensitivity to the ?-carbolines. Respiratory chain inhibition appears to be a possible determinant of the trypanosomicidal activity of these compounds.

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Título de la Revista: Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
Volumen: 122
Número: 1
Editorial: Society of Laparoendoscopic Surgeons
Fecha de publicación: 1999
Página de inicio: 27
Página final: 31
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0032969774&partnerID=q2rCbXpz