Abstract

The rate of acetaldehyde metabolism was measured in aortic rings from rat strains genetically bred for high (UChB) and low (UChA) voluntary ethanol consumption. The results show that in aortic rings from naive UChB rats, acetaldehyde oxidation rates were significantly greater than the rates observed in aortic rings from naive UChA rats. These strain differences are explained by different activity of vascular low-Km aldehyde dehydrogenase (ALDH). Chronic feeding of ethanol to UChA rats did not alter their aortic ALDH activity. The results of the present study provides additional evidence that the activity variation for the low-Km ALDH between both rat strains exists in various organs and tissues.