Article SCOPUS
CLINICAL PEDIATRICS  (2001)

Antipyretic effects of dipyrone versus ibuprofen versus acetaminophen in children: Results of a multinational, randomized, modified double-blind study

Wong, A; Escobar A.M.; Sibbald A.; Ferrero, F; Plager M.; Santolaya M.E.; Campos, S; Barragan S.; De Leon Gonzalez M.; Kesselring G.Lf.

Keywords: temperature, size, toxicity, screening, disease, trial, double-blind, treatment, efficacy, sample, neurotoxicity, gastrointestinal, multicenter, humans, lung, human, male, time, paracetamol, outcome, body, fever, antipyretic, female, urinary, drug, infant, article, child, variance, acetaminophen, tract, analysis, blind, allergy, activity, cardiotoxicity, method, ibuprofen, controlled, preschool, clinical, nose, dipyrone, factors, studies, anti-inflammatory, study, non-steroidal, ear, of, Child,, double, effect, major, prospective, Analgesics,, Non-Narcotic, procedure, randomized, Agents,, throat

Abstract

This study compared the antipyretic effectiveness of acetaminophen, ibuprofen, and dipyrone in young children with fever. The results were based on a modified double-blind, randomized, multinational trial that evaluated 628 febrile children, aged 6 months to 6 years. All three drugs lowered temperature in the 555 patients completing the study. Temperature normalization rates in the ibuprofen and dipyrone groups (78% and 82%, respectively) were significantly higher than the acetaminophen group (68%, P=0.004). After 4 to 6 hours, mean temperature in the dipyrone group was significantly lower than the other groups, demonstrating longer temperature normalization with dipyrone. All three drugs showed comparable tolerability profiles.

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Título según SCOPUS: Antipyretic effects of dipyrone versus ibuprofen versus acetaminophen in children: Results of a multinational, randomized, modified double-blind study
Título de la Revista: CLINICAL PEDIATRICS
Volumen: 40
Número: 6
Editorial: WESTMINSTER PUBL INC
Fecha de publicación: 2001
Página de inicio: 313
Página final: 324
Idioma: English
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034955739&partnerID=q2rCbXpz
Notas: SCOPUS