Article SCOPUS
BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA  (2002)

Antiviral properties of natural and semi-synthetic compounds from Heliotropium filifolium resin Propiedades antivirales de compuestos naturales y semi-sinteticos de la resina de Heliotropium filifolium

Torres R.; Modak,B; Urzúa, A; Delle Monache, F; Pujol E.D.Y.C.A.

Keywords: isolation, synthesis, extract, plant, alcohol, virus, strain, drug, article, ester, filifolium, activity, controlled, heliotropium, study, 3, antiviral, derivative, filifolinone, nonhuman, 2, unclassified, poliomyelitis, filifolinyl, senecionate

Abstract

A new compound called filifolinone 3 was synthesized from the unusual spiranic alcohol filifolinol 1, the principal compound isolated from the resinous exudate of Heliotropium filifolium. (fam.Boraginaceae) Both compounds and the ester derivative of 1, filifolinyl senecionate 2 were tested as antiviral agents against five virus species of importance in human diseases. The most active compound resulted 1, specially against polio virus, but with a tight relationship between antiviral dosis/cytotoxic dosis.

Más información

Título según SCOPUS: Antiviral properties of natural and semi-synthetic compounds from Heliotropium filifolium resin [Propiedades antivirales de compuestos naturales y semi-sinteticos de la resina de Heliotropium filifolium]
Título de la Revista: BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA
Volumen: 47
Número: 3
Editorial: Sociedad Chilena de Química
Fecha de publicación: 2002
Página de inicio: 259
Página final: 263
Idioma: Spanish
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036389098&partnerID=q2rCbXpz
Notas: SCOPUS