Article SCOPUS
ARKIVOC  (2003)

New polyhydroxylated steroids from the marine pulmonate Trimusculusperuvianus

DÍAZ-MARRERO, A. R; Dorta, E; Cueto M.; Darias J.; Rovirosa, J; San Martin, A; Loyola, A.

Keywords: spectroscopy, cell, colon, structure, proton, carcinoma, cytotoxicity, line, resonance, stereochemistry, vitro, nuclear, steroid, carbon, hydroxylation, mollusc, drug, article, analysis, magnetic, study, chemical, in, nonhuman, unclassified, sterol, Trimusculus, peruvianus, diene, 5,24, cholest, 3beta,7beta,21, triol, 7,24, 3alpha,5alpha,6beta, tetrol

Abstract

Two new sterols, 1-2, unusually hydroxylated at C-21 have been isolated from the marine pulmonate Trimusculus peruvianus. Compound 2 possesses a ?7-3?,5?,6?-triol nucleus unprecedented in marine organisms. The structure and stereochemistries were determined on the basis of spectral studies, particularly NMR and MS spectroscopic data. 1 and 2 are the entire sterol content of the mollusk and both exhibit moderate in vitro cytotoxic activity against human colon carcinoma cell lines.

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Título según SCOPUS: New polyhydroxylated steroids from the marine pulmonate Trimusculusperuvianus
Título de la Revista: ARKIVOC
Volumen: 2003
Número: 10
Editorial: ARKAT USA INC
Fecha de publicación: 2003
Página de inicio: 107
Página final: 117
Idioma: English
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-3242722183&partnerID=q2rCbXpz
Notas: SCOPUS