Sex of host and initial dose of inoculum like factors in the development of the infection with Trypanosoma cruzi in a murine model Sexo del hospedero y dosis infectante de parásitos como factores en el desarrollo de la infección con Trypanosoma cruzi en un modelo murino

urzua c; Morales, M.A.; Vergara, U.; Palau M.T.; Zúñiga C.

Abstract

Male and female mice of ACA strain were infected with 200 and 2,000 bloodstream trypomastigotes from Dm 28c clone of Trypanosoma cruzi. All the animals were susceptible to the infection regardless of their sex and dose of initial inoculum used. Both male and female, infected with 2,000 parasites showed significantly higher level of parasitemia than mice infected with the lower dose. At the same time, males developed higher parasitemia level than females, when they were infected with both 200 and 2,000 parasites. Despite of experimental animals behaved as susceptible, the survival period was significantly longer in males infected with 200 trypomastigotes when compared to males infected with 2,000 parasites. Females infected with 2,000 survive a longer time than males infected with the same dose of parasites. No significant differences were observed during the survival period when comparing females infected with 200 and 2,000 parasites, neither in the case of male and female infected with 200 parasites. Apparently, the parasitemia level is the main characteristic affected by the variables sex of the host and initial parasite dose.

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Título según SCOPUS: Sex of host and initial dose of inoculum like factors in the development of the infection with Trypanosoma cruzi in a murine model [Sexo del hospedero y dosis infectante de parásitos como factores en el desarrollo de la infección con Trypanosoma cruzi en un modelo murino]
Título de la Revista: PARASITOLOGIA LATINOAMERICANA
Volumen: 59
Número: 03-abr
Editorial: Sociedad Chilena de Parasitología
Fecha de publicación: 2004
Página de inicio: 104
Página final: 109
Idioma: Spanish
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-34250731140&partnerID=q2rCbXpz
Notas: SCOPUS