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A role of MAP1B in reelin-dependent neuronal migration
Keywords: proteins, system, neurons, adhesion, enzyme, mouse, activation, animals, phosphorylation, movement, brain, protein, cell, gene, microtubule, pregnancy, matrix, synthase, mice, embryo, experiment, transduction, transgenic, migration, deletion, nerve, tissue, reelin, female, signal, rna, cortex, neuronal, article, kinase, translation, correlation, analysis, function, malformation, glycogen, controlled, animal, study, 3, cyclin, priority, nonhuman, journal, Nervous, serine, Cells,, Cultured, associated, Mice,, Cerebral, extracellular, 5, dependent, Microtubule-Associated, Endopeptidases, Molecules,
Abstract
The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration. © Oxford University Press 2004; all rights reserved.
Más información
| Título de la Revista: | CEREBRAL CORTEX |
| Volumen: | 15 |
| Número: | 8 |
| Editorial: | OXFORD UNIV PRESS INC |
| Fecha de publicación: | 2005 |
| Página de inicio: | 1134 |
| Página final: | 1145 |
| URL: | http://www.scopus.com/inward/record.url?eid=2-s2.0-25444431830&partnerID=q2rCbXpz |