Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies

Cerecetto, H.; Gonzalez, M.; Lavaggi M.L.; Aravena M.A.; Rigol, C; Olea Azar C.; Azqueta, A; Lopez De Cerain A.; Monge, A; Bruno A.M.

Keywords: electrochemistry, dna, animals, synthesis, binding, spectrum, cell, design, structure, hypoxia, screening, stress, proton, cytotoxicity, line, resonance, strain, dioxide, vitro, nuclear, interaction, carbon, agent, nitro, drug, quantitative, molecular, article, antineoplastic, analysis, activity, cytotoxins, magnetic, controlled, animal, potentiometry, oxidative, chloroacetamide, cytotoxic, relation, study, 1, v, relationship, derivative, priority, cyclic, in, nonhuman, journal, Structure-Activity, 2, unclassified, Cricetinae, n, (4, yl], yl), tirapazamine, phenazine, quinoxaline, 5,10, Phenazines, (5,10, 7(8), (1,3, dioxolan, yl)phenazin, nitrophenazin, [5,10, phenylpiperazin, yl)acetamide, 79

Abstract

The synthesis and evaluation as hypoxic selective cytotoxins of new derivatives of 2-amino or 2-hydroxyphenazine 5,10-dioxide are described. The compounds were developed as structural analogs of other bioreductive compounds and its in vitro cytotoxicities on V79 cells under hypoxic and aerobic conditions were determined. To gain insight into its mechanism of action electrochemical behavior, interaction with DNA experiments and QSAR studies were performed. © 2006 Bentham Science Publishers Ltd.

Más información

Título según SCOPUS: Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies
Título de la Revista: Medicinal Chemistry
Volumen: 2
Número: 5
Editorial: 1573-4064
Fecha de publicación: 2006
Página de inicio: 511
Página final: 521
Idioma: eng
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-33748664599&partnerID=q2rCbXpz
DOI:

10.2174/157340606778250207

Notas: SCOPUS