Individual and population risk in acute myocardial infarction: The Chilean INTERHEART study Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile

Lanas F.; Lanas A.; Standen, D; POTTHOFF S.; Mercadal, E; Santibáñez C.

Keywords: chile, heart, prevalence, distribution, hypertension, smoking, risk, infarction, trial, multicenter, ratio, humans, human, male, aged, sex, female, dyslipidemia, control, article, factor, case-control, clinical, dyslipidemias, factors, studies, study, middle, case, Odds, Myocardial

Abstract

Background: Acute myocardial infarction (AMI) is the first cause of death in Chile. Aim: To assess the magnitude of risk of individuals and population associated with AMI risk factors. Material and methods: Case control study with incident cases and 2 controls paired by age and gender. History of diabetes, hypertension, smoking, stress, depression, diet, weight, height, hip and waist circumference, apolipoprotein (Apo) A1 and B were determined. Odds ratio (OR) and population attributable risk (PAR) were calculated with 95% confidence interval. Results: Three hundred thirty two cases and 672 controls were included. Mean age was 61.6±12 years and 22% were women. The higher individual risk was associated with smoking: OR 3.1 (2.3-4.2), hypertension: 2.9 (2.1-3.9), permanent stress: 2.2 (1,3-2,8), increased apoB/ApoA1 ratio: 2.1 (1.4-3.0) and diabetes: 2.0 (1.4-2.9). A protective effect of daily consumption of vegetables and/or fruits with and OR of 0.54 (0.4-0.8), was observed. The highest PAR was due to smoking: 42% (33.2-51.4), increased ApoB/ApoA1 ratio: 35.2 (19.0-55.8) and hypertension: 32% (24.5-40.8). These three factors explained 71.3% of the AMI risk in Chile. A moderate effect on PAR was observed for abdominal obesity: 16.6% (2.4-61.2), permanent stress: 12.0% (2.3-44.1) and diabetes: 10.8% (6.1-18.3). Conclusions: Known risk factors like dyslipidemia, smoking and hypertension explain most of the AMI cases in Chile. The control of these risk factors should have a major effect on morbidity and mortality due to coronary artery disease in our country.

Más información

Título según SCOPUS: Individual and population risk in acute myocardial infarction: The Chilean INTERHEART study Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 136
Número: 5
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2008
Página de inicio: 555
Página final: 560
Idioma: eng
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-48849105349&partnerID=q2rCbXpz
Notas: SCOPUS