Article
Letters in Organic Chemistry  (2008)

An efficient synthesis of 2,3-diaryl-2-azabicyclooctanones via BiCl 3 catalysed three-component aza Diels-Alder reaction

Astudillo L.S.; Vallejos G.A.; Correa, N.; Gutierrez M.C.; de la Guarda, W; Kouznetsov, V. V.

Abstract

The first three-component coupling reactions between various anilines (1), benzaldehydes (2), and cyclohexen-2-one (3) were performed under mild conditions (acetonitrile, room temperature, 14 h) in the presence of 20 mol % BiCl 3 to obtain new 2,3-diaryl-2-aza[2.2.2]octan-5-ones (4,5) with interesting acetylcholinesterase inhibitory properties. © 2008 Bentham Science Publishers Ltd.

Más información

Título de la Revista: Letters in Organic Chemistry
Volumen: 5
Número: 7
Editorial: Bentham
Fecha de publicación: 2008
Página de inicio: 559
Página final: 562
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-57349177670&partnerID=q2rCbXpz