Characterization of MgtC, a Virulence Factor of Salmonella enterica Serovar Typhi

Retamal P.; Castillo-Ruiz, M; Mora, GC

Abstract

The MgtC is a virulence factor in Salmonella Typhimurium that is required for growth at low-Mg2+ concentrations and intramacrophage survival. This gene is codified in a conserved region of the Salmonella pathogenicity island 3 (SPI-3), and is also present in the chromosome of other Salmonella serovars. In this study we characterized the MgtC factor in S. Typhi, a human specific pathogen, by using mgtC and SPI-3 mutant strains. We found that MgtC is the most important factor codified in the SPI-3 of S. Typhi for growth in low-Mg2+ media and survival within human cells. In addition, by using reporter genes we determined that the low-Mg2+ concentration, acidic media and PhoP regulator induce mgtC expression in S. Typhi. We suggest that MgtC is the most important virulence factor codified in the SPI-3 of S. Typhi. © 2009 Retamal et al.

Más información

Título según WOS: Characterization of MgtC, a Virulence Factor of Salmonella enterica Serovar Typhi
Título según SCOPUS: Characterization of MgtC, a virulence factor of Salmonella enterica serovar typhi
Título de la Revista: PLOS ONE
Volumen: 4
Número: 5
Editorial: PUBLIC LIBRARY SCIENCE
Fecha de publicación: 2009
Idioma: English
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-65849366314&partnerID=q2rCbXpz
DOI:

10.1371/journal.pone.0005551

Notas: ISI, SCOPUS