Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals Associação entre variantes do gene de leptina e obesidade e biomarcadores metabólicos em indivíduos Brasileiros

Hinuy H.M.; Hirata M.H.; Arazi S.S.; Hirata R.D.C.; Sampaio M.F.; Armaganijan D.; Salazar, L.A.

Keywords: epidemiology, variability, obesity, blood, markers, mass, brazil, variation, humans, human, male, genetics, leptin, aged, index, body, female, article, marker, genetic, methods, middle, biological, Epidemiologic

Abstract

Objective: The relationship between variants of the leptin gene (LEP) and obesity and metabolic biomarkers was investigated in Brazilian individuals. Subjects and methods: One-hundred-ten obese (BMI > 30 kg/m 2) and 100 non-obese individuals (145 women and 65 men, aged 49 ± 14 years) were randomly selected. Plasma leptin, glycemia, serum lipid measurements and LEP -2548G>A and 3'HVR polymorphisms were analyzed. Results: The LEP -2548GG genotype was associated with a 2.2% and 2.0% increase in BMI (p = 0.009) and plasma leptin (p = 0.031), respectively. 3'HVR I/II (classes I/I+I/II) genotypes contributed with 1.8% of BMI values (p = 0.046). LEP I/G combined genotypes (I/IGG, I/IGA and I/IIGG) were associated with obesity, and increased BMI, waist circumference, leptin and triglycerides (p < 0.05). These relationships were found in women (p < 0.05) but not in men. LEP I/G combined genotypes were not associated with hypertension, hyperglycemia, dyslipidemia and coronary artery disease. Conclusions: LEP I/G combined genotypes are associated with obesity-related metabolic biomarkers and phenotype in a gender-dependent manner.

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Título de la Revista: ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA
Volumen: 54
Número: 3
Editorial: SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
Fecha de publicación: 2010
Página de inicio: 282
Página final: 288
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953553843&partnerID=q2rCbXpz