The metabolic syndrome: From an aggravating condition to a pathogenic risk factor for chronic diseases El síndrome metabólico: De factor agravante a principal factor de riesgo patogénico en diversas enfermedades crónicas

von Bernhardi R.; Zanlungo S.; Arrese M.; Rigotti, A.; Arteaga A.

Keywords: chile, risk, disease, humans, cardiovascular, diseases, human, dementia, article, factor, chronic, metabolic, factors, X, syndrome

Abstract

In recent years, a rapidly increasing number of studies have focused on the association between metabolic syndrome and several chronic diseases. However, it is difficult to determine a well defined pathogenic relationship, due to the etiological heterogeneity and comorbidities of these diseases. Research efforts are aiming to identify the convergent biological mechanisms that mediate the effects of hyperinsulinemia, hyperglycemia, dyslipidemia, and hypertension. All these conditions define the metabolic syndrome, that increases the risk for several diseases. The knowledge of these biological mechanisms associated with this syndrome will elucidate the pathogenic association between a variety of chronic diseases, including its pathogenic link with cardiovascular diseases and the most common forms of dementia. The development of new therapeutic and preventive strategies for these diseases will be a corollary of this research.

Más información

Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 138
Número: 8
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2010
Página de inicio: 1012
Página final: 1019
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-78649255334&partnerID=q2rCbXpz