Abstract

This paper describes a novel meta-learning (MTL) based methodology used to optimize a neural network based inference system. The inference system being optimized is part of a bioinformatic application built to implement a systematic search scheme for the identification of genes which encode enzymes of metabolic pathways. Different MTL implementations are contrasted with manually optimized inference systems. The MTL based approach was found to be flexible and able to produce better results than manual optimization. © 2011 Springer-Verlag.