GENOTIPO E3/3 DE APO E Y SU RELACIÓN CON LA RESPUESTA DE LOS LIPIDOS SÉRICOS AL COLESTEROL DIETARIO

Reyes S, María Soledad; Flores C, Ingrid; Riveros S, Claudia; Castillo V, Oscar; Arteaga Ll, Antonio; Acosta B, Ana María; ROZOWSKI N, JAIME

Abstract

Introduction: It has been described in the literature that dietary cholesterol produces only slight changes in serum cholesterol in healthy individuals. Nevertheless, several studies have shown a marked heterogeneity in the response to a variation of cholesterol in the diet. One of the factors involved in this response is the Apo E genotype, also singled as a risk factor for cardiovascular disease. There are no studies in Chile that evaluate the response to dietary cholesterol in individuals and its relationship to the Apo E genotype. Objective: To evaluate the response to a cholesterol load in individuals and relate it to their Apo E genotype. Materials and methods: A prospective randomized and cross-over study was carried out in 36 male volunteers either normolipemics or isolated hypercholesterolemic aged 25-55 years old, who were given one egg/day for 4 weeks in addition to their normal diet. Total, LDL, and HDL cholesterol were measured before and after the intervention, as well as Apo B concentration and Apo E genotype. Results: Apo E genotype was 79% E3/3 and 16% E 4/3 in this population. The addition of one egg to their normal diet did not change significantly any of the variables studied. Conclusions: Normocholesterolemic or hypercholesterolemic individuals did not respond to a load of cholesterol given in the form of one egg/day. The implications for population recommendations are discussed

Más información

Título según SCIELO: GENOTIPO E3/3 DE APO E Y SU RELACIÓN CON LA RESPUESTA DE LOS LIPIDOS SÉRICOS AL COLESTEROL DIETARIO
Título de la Revista: Revista chilena de nutrición
Volumen: 30
Número: 3
Editorial: Sociedad Chilena de Nutrición, Bromatología y Toxicología.
Fecha de publicación: 2003
Página de inicio: 255
Página final: 262
Idioma: es
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182003000300006&lng=en&nrm=iso&tlng=en
DOI:

10.4067/S0717-75182003000300006

Notas: SCIELO