Diagnóstico de la infección poe Helicobacter pylori en niños mediante la detección de antígenos en deposiciones

GONZÁLEZ F, CARMEN GLORIA; SERRANO H, CAROLINA; Harris, Paul R

Abstract

Background: During infancy, preventive, diagnostic and therapeutic efforts for Helicobacter pylori infection should be made. Aim: To evaluate non-invasive diagnostic methods such as stool antigen test (HpSA) and serum anti-H pylori antibody detection (IgG e IgA), compared to endoscopy-based invasive methods (histology and urease test) for the diagnosis of Helicobacter pylori infection. Patients and Methods: Thirty nine children (aged 3 to 14 years, 20 males) referred for upper gastrointestinal endoscopy, were studied. The gold standard to diagnose Helicobacter pylori infection was defined as a positive invasive diagnostic test (histology and/or urease test). Sensitivity (S), specificity (E) and positive (PPV) and negative (NPV) predictive values were obtained for HpSA and serum antibodies. Results: Ten children (26%) were infected with H pylori. S, E, PPV and NPV for HpSA were 90, 100, 100 and 97%, respectively. The figures for serum IgG were 81, 97, 89 and 93%, respectively and for IgA, 90, 76, 36 and 96%, respectively. Conclusions: HpSA was sensitive and specific as a clinical and epidemiological tool to evaluate H pylori infection in children. Serology was not as accurate, but IgG had a better performance than IgA

Más información

Título según SCIELO: Diagnóstico de la infección poe Helicobacter pylori en niños mediante la detección de antígenos en deposiciones
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 135
Número: 2
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2007
Página de inicio: 182
Página final: 188
Idioma: es
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000200006&lng=en&nrm=iso&tlng=en
DOI:

10.4067/S0034-98872007000200006

Notas: SCIELO