Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad

BURROWS A, RAQUEL; Leiva B, Laura; Burgueño A, Medardo; Maggi M, Aida; Giadrosic R, Vinka; Díaz B, Erick; Lera M, Lydia; Albala B Cecilia

Abstract

"Backgrounds: There is a high prevalence of obesity and hyperinsulinism among Chilean prepuberal children. Aim: To evaluate insulin sensitivity (IS) using fasting insulin, the Homeostasis Model Assessment (HOMA) and quantitative insulin-sensitivity check index (QUICKI) in Chilean children. Material and Methods: Body mass index (BMI), total body fat percentage (%TBF) using the sum of 4 skin folds, abdominal obesity determined through waist circumference (WC), pubertal maturation using five Tanner stages, fasting glucose (Glu) and insulin (Ins), were measured in 354 children aged 6 to 15 years (173 males). IS was evaluated using HOMA and QUICKI. Results: IS was strongly associated with %TBF and WC. Ins, HOMA and QUICKI were significantly correlated with BMI (r =0.412; 0.405 y -0.442, respectively), %TBF (r =0.370; 0.367 y -0.394, respectively), and WC (r =0.452; 0.446 y -0.481, respectively). Ins and HOMA increased and QUICKI decreased significantly (p <0.0001) with age. Children in a similar Tanner stage did not have differences in Ins, HOMA and QUICKI. No differences in Ins, HOMA and QUICKI were observed between children in Tanner stages 1 and 2. However, children in Tanner stages 1 and 2, had significantly lower Ins and HOMA and higher QUICKI than those in Tanner 3 to 5 stages. The highest Ins quartile for Tanner stages 1 and 2 was 10.0

Más información

Título según SCIELO: Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 134
Número: 11
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2006
Página de inicio: 1417
Página final: 1426
Idioma: es
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001100009&lng=en&nrm=iso&tlng=en
DOI:

10.4067/S0034-98872006001100009

Notas: SCIELO