Genotipos de virus papiloma humano (VPH) en pacientes con cáncer cervico-uterino en un hospital público y una clínica privada de Santiago, Chile

Valdivia L, Isabel M; Aguayo G, Francisco; Pruyas A, Martha; Snijders, Peter J. F.; Corvalán R, Alejandro; Ferreccio R, Catterina

Abstract

"We compared HPV genotypes among squamous cervical cancer samples from a public hospital (n = 55) and a private clinic (n = 35 cases) of Santiago. Paraffin-embedded specimens were analyzed by PCR followed by an immunoenzimatic assay. Reverse line blotting was used for the identification of 36 HPV genotypes. We found HPVDNAm 94.4% of all cancers. Single mfections: HPV16: 40.0%, (clinic 37.1%, hospital 41.8%) VPH18:7.8% (clinic 2.9%, hospital 10.9%); single+multiple mfections: VPH16: 61.1% (clinic 53.1%, hospital 71.7%), VPH18: 34.4% (clinic 21.9%, hospital 45.2%). HPV16 orHPV18 occurredin 75.6% of cases, higher inthe hospital than the clinic (87.3%-95% CI: 84.9-96.3 - and 57. l%-95% CI: 46.6-66 - respectively, p = 0.002). Other genotypes in single mfections: HPV 26, 31, 33, 45, 58, 67; in co-mfections: HPV 35,52,56,59 and 66. HPV16 but specially HPV 18 were significantly more frequent in the public hospital; 75.6% of squamous cervical cancer were associated to the vaccine preventable HPV16/18."

Más información

Título según SCIELO: Genotipos de virus papiloma humano (VPH) en pacientes con cáncer cervico-uterino en un hospital público y una clínica privada de Santiago, Chile
Título de la Revista: REVISTA CHILENA DE INFECTOLOGIA
Volumen: 27
Número: 1
Editorial: SOC CHILENA INFECTOLOGIA
Fecha de publicación: 2010
Página de inicio: 11
Página final: 15
Idioma: es
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182010000100001&lng=en&nrm=iso&tlng=en
DOI:

10.4067/S0716-10182010000100001

Notas: SCIELO