Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives

Perez-Cruz, F; Serra, S; Delogu G.; Lapier, M.; Maya J.D.; Olea Azar C.; Santana, L; Uriarte, E

Abstract

In the present communication we prepared a series of six 4-hydroxycoumarin derivatives, isosters of quercetin, recognized as an antioxidant natural compound, with the aim of evaluating the antitrypanosomal activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, and the antioxidant properties. We have used the 4-hydroxycoumarin moiety (compound 1) as the molecular template for the synthesis of compounds 2-7. These derivates have shown moderate trypanocidal activity. However they have been proved to be good antioxidants. In particular compound 7 is the most active antioxidant and it is, therefore, a potential candidate for a successful employment in conditions characterized by free radicals overproduction. © 2012 Elsevier Ltd. All rights reserved.

Más información

Título según WOS: Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives
Título según SCOPUS: Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives
Título de la Revista: BIOORGANIC MEDICINAL CHEMISTRY LETTERS
Volumen: 22
Número: 17
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2012
Página de inicio: 5569
Página final: 5573
Idioma: English
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865145129&partnerID=40&md5=cb1e38d3e4af416a0d14c5688f9eaa9f
DOI:

10.1016/j.bmcl.2012.07.013

Notas: ISI, SCOPUS