PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS

Madrid, Alejandro; Espinoza, Luis; CATALÁN, KAREN; González, César; MONTENEGRO, IVÁN; Mellado, Marco; Werner, Enrique; Cuellar, Mauricio; Villena, Joan

Abstract

"Vanillin, o-vanillin, natural and synthetic benzaldehydes and benzyl alcohols were assessed for antiproliferative effects using different human cell lines. Benzyl alcohols were synthesized from benzaldehydes reduced with NaBH4 in methanol solution. A new method for deprotection of ether compounds with TiCl4 solution was achieved with better performance, than previously reported. Twenty four compounds were tested. The in vitro growth inhibition assay was based on sulphorhodamine dye to quantify cell viability. Catechol 9 derived from piperonal as well as compounds 4 and 12 showed higher cytotoxicity on breast and prostate cancer cell lines (MDA-MB-231 and PC-3 respectively). o-Vanillin 5 has the highest cytotoxicity for all cell lines. IC50 values of 35.40 ± 4.2 μM Breast MDA-MB231; 47.10 ± 3.8 μM Prostate PC-3; 72.50 + 5.4 μM Prostate DU-145; 85.10 + 6.5 μM and Colon HT-29, were obtained without toxicity towards dermal human fibroblast (DHF cells)."

Más información

Título según WOS: PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS
Título según SCOPUS: Preliminary antiproliferative evaluation of natural, synthetic benzaldehydes and benzyl alcohols
Título según SCIELO: PRELIMINARY ANTIPROLIFERATIVE EVALUATION OF NATURAL,-SYNTHETIC BENZALDEHYDES AND BENZYL ALCOHOLS
Título de la Revista: JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
Volumen: 58
Número: 3
Editorial: 2013
Fecha de publicación: 2013
Página de inicio: 1814
Página final: 1816
Idioma: en
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000300003&lng=en&nrm=iso&tlng=en
DOI:

10.4067/S0717-97072013000300003

Notas: ISI, SCIELO, SCOPUS