Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins

Matos, MJ; Perez-Cruz, F; Vazquez-Rodriguez, S; Uriarte, E; Santana, L; Borges, F; Olea Azar C.

Abstract

In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1-9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical evaluation of ADME properties of all the derivatives was also carried. out. From the ORAC-FL, ESR and CV data it was concluded that these derivatives are very good antioxidants, with a very interesting hydroxyl, DPPH and superoxide radicals scavenging profiles. In particular compound 9 is the most active and effective antioxidant of the series (ORAC-FL = 13.5, capacity of scavenging hydroxyl radicals = 100%, capacity of scavenging DPPH radicals = 65.9% and capacity of scavenging superoxide radicals = 71.5%). Kinetics profile for protection fluorescein probe against peroxyl radicals by addition of antioxidant molecule 9 was also performed. Therefore, it can operate as a potential candidate for preventing or minimizing the free radicals overproduction in oxidative-stress related diseases. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

Más información

Título según WOS: Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins
Título según SCOPUS: Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins
Título de la Revista: BIOORGANIC & MEDICINAL CHEMISTRY
Volumen: 21
Número: 13
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2013
Página de inicio: 3900
Página final: 3906
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0968089613003325
DOI:

10.1016/j.bmc.2013.04.015

Notas: ISI, SCOPUS