Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins
Abstract
In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1-9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical evaluation of ADME properties of all the derivatives was also carried. out. From the ORAC-FL, ESR and CV data it was concluded that these derivatives are very good antioxidants, with a very interesting hydroxyl, DPPH and superoxide radicals scavenging profiles. In particular compound 9 is the most active and effective antioxidant of the series (ORAC-FL = 13.5, capacity of scavenging hydroxyl radicals = 100%, capacity of scavenging DPPH radicals = 65.9% and capacity of scavenging superoxide radicals = 71.5%). Kinetics profile for protection fluorescein probe against peroxyl radicals by addition of antioxidant molecule 9 was also performed. Therefore, it can operate as a potential candidate for preventing or minimizing the free radicals overproduction in oxidative-stress related diseases. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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Título según WOS: | Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins |
Título según SCOPUS: | Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins |
Título de la Revista: | BIOORGANIC & MEDICINAL CHEMISTRY |
Volumen: | 21 |
Número: | 13 |
Editorial: | PERGAMON-ELSEVIER SCIENCE LTD |
Fecha de publicación: | 2013 |
Página de inicio: | 3900 |
Página final: | 3906 |
Idioma: | English |
URL: | http://linkinghub.elsevier.com/retrieve/pii/S0968089613003325 |
DOI: |
10.1016/j.bmc.2013.04.015 |
Notas: | ISI, SCOPUS |