Abstract

Objectives: The aim of this study was to identify and prioritize research gaps to help decrease maternal mortality. Study Design and Setting: We conducted a two-stage survey. We provided participants (Cochrane Collaboration experts) with a list of 319 problem/population, intervention, comparison, and outcome questions built from 178 Cochrane systematic reviews. Questions were classified according to causes of maternal death. Respondents of the first round refined the research questions and prioritized them by eliminating those that were considered of low priority, according to four criteria. They also included additional questions. In the second round, respondents prioritized 62 questions. Results: The overall response rates for the first and second rounds were 47% (73 of 155) and 17% (363 of 2,121), respectively. Participants ranked 62 of the research questions as very relevant. Approximately 20% of all questions that were identified in Cochrane reviews and two-third of questions of the second round were considered of very high priority. More women (235) than men (128) participated in the survey. We did not find statistically significant differences when comparing the groups of very relevant questions by the type of respondent, income, country, and round. Conclusion: We identified research priorities by mapping and improving the understanding of research needs in low- and middleincome settings internationally. (C) 2014 Elsevier Inc. All rights reserved.