Signaling Pathways Involved in Neuron-Astrocyte Adhesion and Migration

Cardenas, A; Kong M.; Alvarez A.; Maldonado, H.; Leyton, L

Abstract

Astrocytes in the normal brain possess a stellate shape reflecting their non-migratory properties. Alternatively, in neurodegenerative diseases or after injury, astrocytes become reactive in a process known as astrocytosis or reactive gliosis, retract their processes, become polarized and acquire front-to-rear asymmetry typical of migratory cells. On the other hand, neuronal migration is a common process during embryonic development, but only few types of neurons can migrate and differentiate during adult life in the central nervous system. Those that do migrate follow tracks made by glial cells and mainly give rise to interneurons. In vitro, molecular mechanisms involved in adhesion of cells to and migration on extracellular matrix proteins have been widely studied; however, signal transduction pathways explaining how particularly neurons and astrocytes, mutually modulate adhesion and migration are less well known. In this review, we describe and discuss how ligand/receptor interactions in astrocytes and neurons trigger signaling events leading to actin and microtubule reorganization, changes in cell morphology, as well as cell adhesion and migration. The biological significance these cell-cell interactions and signaling events might have in the brain are discussed.

Más información

Título según WOS: Signaling Pathways Involved in Neuron-Astrocyte Adhesion and Migration
Título de la Revista: CURRENT MOLECULAR MEDICINE
Volumen: 14
Número: 2
Editorial: BENTHAM SCIENCE PUBL LTD
Fecha de publicación: 2014
Página de inicio: 275
Página final: 290
Idioma: English
Notas: ISI