The MAP1B Case: An Old MAP That is New Again

Villarroel-Campos D and Gonzalez-Billault C.

Abstract

The functions of microtubule-associated protein 1B (MAP1B) have historically been linked to the development of the nervous system, based on its very early expression in neurons and glial cells. Moreover, mice in which MAP1B is genetically inactivated have been used extensively to show its role in axonal elongation, neuronal migration, and axonal guidance. In the last few years, it has become apparent that MAP1B has other cellular and molecular functions that are not related to its microtubule-stabilizing properties in the embryonic and adult brain. In this review, we present a systematic review of the canonical and novel functions of MAP1B and propose that, in addition to regulating the polymerization of microtubule and actin microfilaments, MAP1B also acts as a signaling protein involved in normal physiology and pathological conditions in the nervous system. (c) 2014 Wiley Periodicals, Inc.

Más información

Título según WOS: The MAP1B Case: An Old MAP That is New Again
Título según SCOPUS: The MAP1B case: An old MAP that is new again
Título de la Revista: Developmental Neurobiology
Volumen: 74
Número: 10
Editorial: WILEY-BLACKWELL
Fecha de publicación: 2014
Página de inicio: 953
Página final: 971
Idioma: English
DOI:

10.1002/dneu.22178

Notas: ISI, SCOPUS - ISI