Susceptibility to apoptosis is enhanced in immature cortical neurons.

McDonald, J.W.; Behrens, M. I.; Chung, C; Bhattacharyya, T; Choi, DW

Abstract

The susceptibility of cortical neurons to two forms of apoptotic death was compared with susceptibility to excitotoxic death during development in vitro (DIV 4-21). Murine cortical cultures were exposed for 48 h to the phosphatase inhibitor cyclosporine, the protein kinase inhibitor staurosporine or the excitotoxin N-methyl-D-aspartate (NMDA). Susceptibility to apoptosis induced by staurosporine or cyclosporine was maximal between DIV 4-10 and declined from DIV 10 through 18. The opposite pattern was observed with susceptibility to NMDA receptor-mediated excitotoxic necrosis, which was minimal at DIV 6 and progressively increased through DIV 21.

Más información

Título de la Revista: Brain research
Volumen: 759
Número: 2
Editorial: Elsevier
Fecha de publicación: 1997
Página de inicio: 228
Página final: 232
Idioma: English
Notas: ISI