Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

hetz C.; Mollereau, B

Abstract

The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well characterized in non-neuronal cells, a proliferation of papers over the past few years has revealed a key role for the UPR in normal neuronal function and as an important driver of neurodegenerative diseases. A complex scenario is emerging in which distinct UPR signalling modules have specific and even opposite effects on neurodegeneration depending on the disease context. Here, we provide an overview of the most recent findings addressing the biological relevance of ER stress in the nervous system.

Más información

Título según WOS: Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
Título según SCOPUS: Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
Título de la Revista: NATURE REVIEWS NEUROSCIENCE
Volumen: 15
Número: 4
Editorial: Nature Publishing Group
Fecha de publicación: 2014
Página de inicio: 233
Página final: 249
Idioma: English
DOI:

10.1038/nrn3689

Notas: ISI, SCOPUS