INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA

GERARDO C; Mario Silva; José Becerra; Homero, Urrutia; Katherine Sossa; Cristian Paz

Abstract

Fifteen native Chilean plants were evaluated against the quorum sensing (QS) biosensor AI-1, Chromobacterium violaceum ATCC 12472. Three extracts showed inhibitory activity of QS: Drymis winteri J.R, Psoralea glandulosa L and Peumus boldus. Purification of secondary metabolites from barks of Drimys winteri showed that drimane sesquiterpenes were the main compounds in the tree. Polygodial, drimenol, isodrimeninol, drimenin, isodrimenin, cinnamolide and valdiviolide were isolated and evaluated in QS inhibition assays. Two alpha,beta unsaturated lactones, cinnamolide and valdiviolide, with the carbonyl on position 12 of the drimane skeleton were found to be inhibitors of QS; other drimane lactones were not active.

Más información

Título según WOS: INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA
Título según SCOPUS: Inhibition of quorum sensing by drimane lactones from chilean Flora
Título según SCIELO: INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA
Título de la Revista: JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
Volumen: 59
Número: 3
Editorial: 2013
Fecha de publicación: 2014
Página de inicio: 2622
Página final: 2624
Idioma: English
DOI:

10.4067/S0717-97072014000300021

Notas: ISI, SCIELO, SCOPUS